| Pair Name | Hyaluronic acid, Doxorubicin | ||
| Phytochemical Name | Hyaluronic acid (PubChem CID: / ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Hyaluronic acid, Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Immunomodulatory | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 | |
| In Vivo Model | Breast cancer xenograft mouse model was constructed by transplanting 4T1 cells subcutaneously to the nude mice and used in the following experiments at 10 d after inoculation | |||
| Result | This multifunctional nanoparticle system could deliver R848 and DOX respectively to tumor microenvironment and breast cancer cells to achieve synergistic effects of immunotherapy and chemotherapy against breast cancer. | |||
| No. | Title | Href |
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| 1 | Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy. Acta Biomater. 2018 Jan 15;66:310-324. doi: 10.1016/j.actbio.2017.11.010. | Click |
